Hemophilia A treatment: disruptive technology ahead

Nano-technology: a Disruptive Technology?

Disruptive Technology

The term "disruptive technology" as coined by Christensen (1997) refers to a new technology having lower cost and performance measured by traditional criteria, but having higher ancillary performance. Christensen finds that disruptive technologies may enter and expand emerging market niches, improving with time and ultimately attacking established products in their traditional markets. This con...

A novel, disruptive vaccination technology

Nucleotide based vaccines represent an enticing, novel approach to vaccination. We have developed a novel immunization technology, RNActive(®) vaccines, that have two important characteristics: mRNA molecules are used whose protein expression capacity has been enhanced by 4 to 5 orders of magnitude by modifications of the nucleotide sequence with the naturally occurring nucleotides A (adenosine...

Rituximab for Treatment of Hemophilia A with High-Responder Inhibitors

Background: The development of inhibitors is a complication factor replacement therapy in hereditary factor VIII deficiency. Several management options are available for the treatment of inhibitor. Rituximab, a monoclonal antibody against CD20, reduces inhibitor level in rare bleeding disorders. The aim of this study was to evaluate the effectiveness of rituximab in lowering or eliminating the ...

The e-book phenomenon: a disruptive technology

Introduction. The e-book and its associated technology have emerged as a disruptive technology over the past ten years. The aim of this paper is to discuss some of the consequences of this development, based on the work of the e-books in Sweden research project. Argument. To explain the impact of the e-book phenomenon we use Winston’s theory of technological innovation, with particular referenc...